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Loss of VLA-2 collagen receptor in breast carcinoma, facilitating invasion and metastasis.

Abstract
The integrin VLA-2 as a collagen receptor and VLA-5 as a fibronectin receptor were detected immunohistochemically in normal, benign tumor and carcinoma tissues of the breast. Both proteins were also detected by Western-blot analysis in some carcinoma cases. Epithelial and myoepithelial cells of both normal breast and benign tumor were in all cases immunoreactive for VLA-2 in the plasma membrane. Carcinoma cells in the invasive component were not immunoreactive for VLA-2 in 31 (46%) of 67 cases. Carcinoma cells in the intraductal components were negative for VLA-2 in only 4 (11%) of 36 cases, while 20 cases (56%) showed weak expression and 12 cases (33%) showed strong expression. Metastatic carcinoma cells in the lymph nodes of 6 cases showed no immunoreactivity except in one case, whereas, again with the exception of one case, the carcinoma cells in the primary tumors did show VLA-2 expression. With regard to VLA-5, there was no difference in its expression in the invasive components and the intraductal components. These findings suggest that the loss of VLA-2 plays a role in the invasion and metastasis of breast carcinoma.
AuthorsK Arihiro, K Inai, K Kurihara, S Takeda, M Kaneko, K Kuroi, T Toge
JournalJapanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 84 Issue 7 Pg. 726-33 (Jul 1993) ISSN: 0910-5050 [Print] Japan
PMID8396565 (Publication Type: Journal Article)
Chemical References
  • Receptors, Cell Surface
  • Receptors, Collagen
  • Receptors, Fibronectin
  • Receptors, Very Late Antigen
Topics
  • Adult
  • Aged
  • Breast (chemistry)
  • Breast Neoplasms (chemistry, pathology)
  • Carcinoma, Intraductal, Noninfiltrating (chemistry, pathology)
  • Female
  • Fibrocystic Breast Disease (chemistry, pathology)
  • Humans
  • Lymphatic Metastasis
  • Middle Aged
  • Neoplasm Invasiveness
  • Receptors, Cell Surface (analysis)
  • Receptors, Collagen
  • Receptors, Fibronectin (analysis)
  • Receptors, Very Late Antigen (analysis)

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