Abstract |
The integrin VLA-2 as a collagen receptor and VLA-5 as a fibronectin receptor were detected immunohistochemically in normal, benign tumor and carcinoma tissues of the breast. Both proteins were also detected by Western-blot analysis in some carcinoma cases. Epithelial and myoepithelial cells of both normal breast and benign tumor were in all cases immunoreactive for VLA-2 in the plasma membrane. Carcinoma cells in the invasive component were not immunoreactive for VLA-2 in 31 (46%) of 67 cases. Carcinoma cells in the intraductal components were negative for VLA-2 in only 4 (11%) of 36 cases, while 20 cases (56%) showed weak expression and 12 cases (33%) showed strong expression. Metastatic carcinoma cells in the lymph nodes of 6 cases showed no immunoreactivity except in one case, whereas, again with the exception of one case, the carcinoma cells in the primary tumors did show VLA-2 expression. With regard to VLA-5, there was no difference in its expression in the invasive components and the intraductal components. These findings suggest that the loss of VLA-2 plays a role in the invasion and metastasis of breast carcinoma.
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Authors | K Arihiro, K Inai, K Kurihara, S Takeda, M Kaneko, K Kuroi, T Toge |
Journal | Japanese journal of cancer research : Gann
(Jpn J Cancer Res)
Vol. 84
Issue 7
Pg. 726-33
(Jul 1993)
ISSN: 0910-5050 [Print] Japan |
PMID | 8396565
(Publication Type: Journal Article)
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Chemical References |
- Receptors, Cell Surface
- Receptors, Collagen
- Receptors, Fibronectin
- Receptors, Very Late Antigen
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Topics |
- Adult
- Aged
- Breast
(chemistry)
- Breast Neoplasms
(chemistry, pathology)
- Carcinoma, Intraductal, Noninfiltrating
(chemistry, pathology)
- Female
- Fibrocystic Breast Disease
(chemistry, pathology)
- Humans
- Lymphatic Metastasis
- Middle Aged
- Neoplasm Invasiveness
- Receptors, Cell Surface
(analysis)
- Receptors, Collagen
- Receptors, Fibronectin
(analysis)
- Receptors, Very Late Antigen
(analysis)
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