Bladder preservation and durable complete remission of small cell carcinoma of the bladder with systemic chemotherapy and adjuvant radiation therapy.

Abstract

BACKGROUND:

Small cell (oat cell) carcinoma of the bladder is a rare entity characterized clinically by an aggressive behavior with a high incidence of systemic metastases. Radical cystectomy has been the therapeutic focal point for this disease, but systemic relapse is almost universal.

RESULTS:

The authors report that combination chemotherapy with cisplatin, methotrexate, and vinblastine, followed by external beam irradiation to the bladder, gave a durable continuous complete remission (more than 4.5 years). In addition, this bladder-sparing approach has preserved normal bladder function and an excellent quality of life.

CONCLUSION:

This experience shows that radical cystectomy may not be necessary for small cell carcinoma of the bladder and that early intervention with systemic chemotherapy offers greater potential for cure.

• Authors: D J Oblon, J T Parsons, D S Zander, Z Wajsman
• Journal: Cancer (Cancer) Vol. 71 Issue 8 Pg. 2581-4 (Apr 15 1993) ISSN: 0008-543X [Print] United States
• PMID: 8384071 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vinblastine
• Cisplatin
• Methotrexate

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Small Cell (drug therapy, pathology, radiotherapy)
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Drug Administration Schedule
• Humans
• Male
• Methotrexate (administration & dosage)
• Middle Aged
• Radiotherapy Dosage
• Remission Induction
• Urinary Bladder Neoplasms (drug therapy, pathology, radiotherapy)
• Vinblastine (administration & dosage)