Abstract |
The histologic changes in the temporo mandibular joint (TMJ) and the activity of serum collagenase-like ( CL) peptidase and prolyl endopeptidase (PEP) were compared in mice with spontaneous osteoarthrosis (C57 black mouse/6 Silverberg (C57BL/6S) and control mice (C57 black mouse/6N (C57BL/6N) and ddY). The onset of osteoarthrosis of the TMJ in the C57BL/6S mice was noted at 12 weeks of age. Clefting in the chondrocyte layer was noted at 24 to 36 weeks of age; chondrocyte cluster and pannus at 36 to 60 weeks of age; and clefts deep in the bone and formation of osteophytes at 72 to 96 weeks of age. CL-peptidase and PEP activity significantly higher in C57BL/6S mice than in osteoarthrosis-free C57BL/6N and ddY mice. These changes occurred at an earlier age than the histologic changes. The findings suggest that these enzymes may play a significant role in the onset of osteoarthrosis in joints.
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Authors | Y Fukuoka, M Hagihara, T Nagatsu, T Kaneda |
Journal | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
(J Oral Maxillofac Surg)
Vol. 51
Issue 3
Pg. 288-91
(Mar 1993)
ISSN: 0278-2391 [Print] United States |
PMID | 8383194
(Publication Type: Journal Article)
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Chemical References |
- Collagen
- Serine Endopeptidases
- Prolyl Oligopeptidases
- Microbial Collagenase
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Topics |
- Animals
- Cartilage, Articular
(pathology)
- Collagen
(metabolism)
- Female
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Microbial Collagenase
(blood)
- Osteoarthritis
(enzymology, pathology)
- Prolyl Oligopeptidases
- Serine Endopeptidases
(blood)
- Synovial Membrane
(pathology)
- Temporomandibular Joint Disorders
(enzymology, pathology)
- Time Factors
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