[Adult T cell leukemia/lymphoma effectively treated with chronic oral etoposide].

Abstract

A 52-year-old man, who complained of tarry stool and systemic lymphadenopathy, was admitted to our hospital on July 2, 1992. Biopsy showed diffuse large cell lymphoma. Leukocytosis with atypical lymphocytes was not shown in the peripheral blood, but there was an elevated serum LDH level. The man was found to have both HTLV-I antibody and the monoclonal integration of proviral DNA in malignant lymph node cells obtained at biopsy. The diagnosis was lymphoma-type adult T-cell leukemia (ATLL). The chemotherapy regimens of MI-FP, CHOP and modified DHAP were used for the treatment, but were not effective. So, he was treated with etoposide 75 mg orally for 25 days (chronic oral etoposide therapy) and achieved partial remission. This chemotherapy induced myelosuppression with neutropenia, but there was no documented infection. Chronic oral etoposide therapy is an effective regimen for patients with relapse or refractory lymphoma.

• Authors: T Yamane, K Ohta, Y Nakao, Y Yasui, K Shindo, K Tanaka, T Hasuike, M Hirai, K Takekawa, N Hirai
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 20 Issue 12 Pg. 1853-6 (Sep 1993) ISSN: 0385-0684 [Print] Japan
• PMID: 8379679 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Etoposide

Topics

• Administration, Oral
• Drug Administration Schedule
• Etoposide (administration & dosage)
• Humans
• Leukemia-Lymphoma, Adult T-Cell (drug therapy, pathology)
• Male
• Middle Aged
• Remission Induction