HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Positron emission tomography in myotonic dystrophy.

Abstract
Regional cerebral glucose metabolism (rCMRG1) was studied in three patients with myotonic dystrophy by positron emission tomography with 18F-2-fluoro-2-deoxy-D-glucose as the radiotracer. Clinically, all patients presented an organic personality syndrome. Impairment of rCMRG1 was found in all cortical and subcortical regions, particularly in the frontal cortex and the lentiform nucleus. The results suggest that the organic personality changes that occur in myotonic dystrophy reflect widespread cerebral pathology. The metabolic pattern was similar to that seen in normal aging but was qualitatively more severe and is therefore consistent with the classification of myotonic dystrophy as a progeric disease.
AuthorsR Mielke, K Herholz, G Fink, D Ritter, W D Heiss
JournalPsychiatry research (Psychiatry Res) Vol. 50 Issue 2 Pg. 93-9 (Jun 1993) ISSN: 0165-1781 [Print] Ireland
PMID8378492 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Fluorodeoxyglucose F18
  • Deoxyglucose
  • Glucose
Topics
  • Adult
  • Basal Ganglia (diagnostic imaging, metabolism)
  • Brain (diagnostic imaging, metabolism)
  • Cerebrovascular Circulation
  • Deoxyglucose (analogs & derivatives)
  • Female
  • Fluorodeoxyglucose F18
  • Glucose (metabolism)
  • Humans
  • Male
  • Middle Aged
  • Myotonic Dystrophy (diagnostic imaging, genetics, metabolism)
  • Tomography, Emission-Computed

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: