Abstract | PURPOSE: METHODS: RESULTS: The three concentrations of PhXA41 reduced the average IOP between 31% and 38% during the second day of treatment, with only a weak dose-response relationship. The initial effect declined somewhat during the first 2 weeks of treatment but then remained at the same level for the rest of the study, with a pressure reduction of approximately 20% for all three concentrations. On the second day of treatment, mild conjunctival hyperemia could be observed in most treated patients. Nineteen of 45 PhXA41-treated patients, compared with 2 of 15 placebo-treated patients, reported to have mild to moderate ocular irritation. These side effects became less pronounced during the study, and at the end there was little difference in the degree of conjunctival hyperemia between placebo- and drug-treated eyes, and no drug-related ocular irritation was reported with the two lowest concentrations of PhXA41. CONCLUSIONS: It is confirmed that the PGF2 alpha analog PhXA41 is a major improvement with respect to the effect-side effect relationship and that it may become a valuable new agent for the treatment of glaucoma.
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Authors | A Alm, J Villumsen, P Törnquist, A Mandahl, J Airaksinen, A Tuulonen, A Marsk, B Resul, J Stjernschantz |
Journal | Ophthalmology
(Ophthalmology)
Vol. 100
Issue 9
Pg. 1312-6; discussion 1316-7
(Sep 1993)
ISSN: 0161-6420 [Print] United States |
PMID | 8371917
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S., Comment)
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Chemical References |
- Ophthalmic Solutions
- Prostaglandins F, Synthetic
- Latanoprost
|
Topics |
- Adult
- Conjunctival Diseases
(chemically induced)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Glaucoma, Open-Angle
(drug therapy)
- Humans
- Hyperemia
(chemically induced)
- Intraocular Pressure
(drug effects)
- Latanoprost
- Longitudinal Studies
- Male
- Ocular Hypertension
(drug therapy, physiopathology)
- Ophthalmic Solutions
- Prostaglandins F, Synthetic
(administration & dosage, adverse effects, therapeutic use)
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