Abstract | BACKGROUND: MATERIAL AND METHODS: Nineteen patients (aged 48 +/- 15 years) with mild hypertension (mean arterial pressure automatically recorded for 24 hours with blood pressure ambulatorial monitoring) were treated with cilazapril (5 mg/day) for 1 year. Doppler echocardiography was performed: at the beginning, after 6 months and after one year of therapy. The following parameters were evaluated: interventricular septal and posterior wall thickness, LV end-diastolic diameter, LV mass index, early (E) and late (A) diastolic filling flow velocities and the ratio E/A. RESULTS: A significant decrease was observed in mean arterial pressure (from 130 +/- 14 mmHg at beginning to 102 +/- 11 mmHg at six months of therapy and to 103 +/- 9 mmHg at one year of therapy). A significant reduction in LV hypertrophy and an improved diastolic filling pattern of the left ventricle was shown after six months of therapy with cilazapril; this improvement still remained after 1 year of therapy. CONCLUSIONS:
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Authors | R De Simone, L Irace, B Perna, C Caruso, M Guida, A Iacono |
Journal | Minerva cardioangiologica
(Minerva Cardioangiol)
Vol. 41
Issue 5
Pg. 205-9
(May 1993)
ISSN: 0026-4725 [Print] Italy |
Vernacular Title | Effetti del trattamento con cilazapril sul riempimento diastolico e sulla ipertrofia ventricolare sinistra in pazienti con ipertensione arteriosa. |
PMID | 8355860
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Antihypertensive Agents
- Cilazapril
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Topics |
- Adolescent
- Adult
- Aged
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology, therapeutic use)
- Antihypertensive Agents
(pharmacology, therapeutic use)
- Cilazapril
(pharmacology, therapeutic use)
- Diastole
(drug effects)
- Drug Evaluation
- Echocardiography
- Female
- Humans
- Hypertension
(drug therapy, physiopathology)
- Hypertrophy, Left Ventricular
(drug therapy, physiopathology)
- Male
- Middle Aged
- Ventricular Function, Left
(drug effects)
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