Recombinant interleukin-1 receptor antagonist protein prevents sensitization and intestinal anaphylaxis in guinea pigs.

Abstract

Recombinant interleukin-1 receptor antagonist protein (rlRAP, 0.5 mg/kg) administered intraperitoneally in guinea pigs one hour before primary and booster parenteral sensitization (1 ml) by cow milk, led to a reduced immunoglobulin E (IgE) production, as displayed by a passive cutaneous anaphylaxis test. rlRAP administered intraperitoneally in sensitized guinea pigs at 0.5 mg/kg 10 min before challenge administration (beta-lactoglobulin, 100 mg per os), also prevents the colonic motor and secretory changes induced by intestinal anaphylaxis. These results suggest the involvement of interleukin-1 in food allergy and evidence a double protective role for rlRAP in food hypersensitivity.

• Authors: V Theodorou, J Fioramonti, L Bueno
• Journal: Life sciences (Life Sci) Vol. 53 Issue 9 Pg. 733-8 ( 1993) ISSN: 0024-3205 [Print] Netherlands
• PMID: 8355572 (Publication Type: Journal Article)

Chemical References

• Antigens
• Interleukin 1 Receptor Antagonist Protein
• Interleukin-1
• Lactoglobulins
• Recombinant Proteins
• Sialoglycoproteins

Topics

• Anaphylaxis (immunology, prevention & control)
• Animals
• Antigens (immunology, pharmacology)
• Colon (drug effects, metabolism, physiology)
• Gastrointestinal Transit (drug effects, physiology)
• Guinea Pigs
• Immunization
• Interleukin 1 Receptor Antagonist Protein
• Interleukin-1 (therapeutic use)
• Intestinal Diseases (immunology, prevention & control)
• Lactoglobulins (adverse effects)
• Male
• Milk Hypersensitivity (immunology, prevention & control)
• Motor Activity (drug effects)
• Recombinant Proteins (therapeutic use)
• Sialoglycoproteins (therapeutic use)