Complement component C3-derived neutrophil chemotactic factors purified from exudate of rat carrageenin-induced inflammation.

Abstract

Two neutrophil chemotactic factors have been purified from the exudate of chronic-phase of rat carrageenin-induced inflammation. Both the factors were derived from the third component of complement (C3); one was an NH2-terminal fragment (C3a) of alpha chain of C3 and another chemoattractant was a COOH-terminal fragment of beta chain, which was referred to as C3 beta c, on the basis of their molecular masses and NH2-terminal amino acid sequences. C3a exhibits potent chemotactic activity for rat neutrophils, and C3 beta c is a novel basic neutrophil chemoattractant with molecular mass of about 11 kDa, suggesting that both chemoattractants play a role in the neutrophil infiltration into inflammatory site of carrageenin-induced inflammation in rats.

• Authors: H Nakagawa, N Komorita
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 194 Issue 3 Pg. 1181-7 (Aug 16 1993) ISSN: 0006-291X [Print] United States
• PMID: 8352775 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• C3 beta c
• Chemotactic Factors
• Complement C3
• Peptide Fragments
• Complement C3a
• Complement C3b
• Carrageenan

Topics

• Amino Acid Sequence
• Animals
• Carrageenan (pharmacology)
• Chemotactic Factors (isolation & purification)
• Chemotaxis, Leukocyte (physiology)
• Complement C3 (isolation & purification, metabolism)
• Complement C3a (isolation & purification, metabolism)
• Complement C3b
• Granulation Tissue (chemistry)
• Inflammation (chemically induced, metabolism)
• Male
• Molecular Sequence Data
• Neutrophils (physiology)
• Peptide Fragments (isolation & purification, metabolism)
• Rats
• Rats, Wistar