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Protective efficacy of BCG vaccine against leprosy in southern Malaŵi.

Abstract
This paper describes a matched case-control study to determine the efficacy of BCG vaccine in preventing the occurrence of leprosy in southern Malaŵi, a previously unstudied area. The BCG immunization rate amongst 145 individuals with leprosy was 44.8%, compared to 62.5% in 290 matched controls. The protective efficacy of BCG vaccine against leprosy in this region was estimated to be 63.6%; smallpox immunization had no effect. These findings support the view that BCG vaccine should be considered as a control measure in areas where leprosy is endemic.
AuthorsD M Baker, J S Nguyen-Van-Tam, S J Smith
JournalEpidemiology and infection (Epidemiol Infect) Vol. 111 Issue 1 Pg. 21-5 (Aug 1993) ISSN: 0950-2688 [Print] England
PMID8348929 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • BCG Vaccine
Topics
  • Adolescent
  • Adult
  • BCG Vaccine
  • Case-Control Studies
  • Female
  • Humans
  • Leprosy (prevention & control)
  • Malawi (epidemiology)
  • Male
  • Odds Ratio

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