Absence of an association between HLA-DRB1*04 and rheumatoid arthritis in newly diagnosed cases from the community.

Abstract

OBJECTIVES:

To determine HLA-DR4 and DR1 allele frequencies in a series of patients with newly diagnosed early inflammatory arthritis.

METHODS:

HLA-DR1 and DR4 frequencies were determined by oligonucleotide typing of 208 patients classified as having either rheumatoid arthritis (RA) or undifferentiated inflammatory polyarthritis.

RESULTS:

The frequency of occurrence of DR4 in these patients with RA did not differ significantly from that in controls in the United Kingdom (42 v 37%). HLA-DR1 was increased in the group with inflammatory polyarthritis (25 v 18%).

CONCLUSIONS:

The frequency of DR4 is not increased in newly diagnosed community based patients with RA. This supports the hypothesis that DR4 is less important as a marker for susceptibility to RA than it is for disease persistence or severity.

• Authors: W Thomson, L Pepper, A Payton, D Carthy, D Scott, W Ollier, A Silman, D Symmons
• Journal: Annals of the rheumatic diseases (Ann Rheum Dis) Vol. 52 Issue 7 Pg. 539-41 (Jul 1993) ISSN: 0003-4967 [Print] England
• PMID: 8346982 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-DR Antigens
• HLA-DR1 Antigen
• HLA-DR4 Antigen
• HLA-DRB1 Chains
• Histocompatibility Antigens Class II
• Oligonucleotide Probes

Topics

• Arthritis, Rheumatoid (genetics)
• Base Sequence
• Genes, MHC Class II (genetics)
• HLA-DR Antigens (genetics)
• HLA-DR1 Antigen (genetics)
• HLA-DR4 Antigen (genetics)
• HLA-DRB1 Chains
• Histocompatibility Antigens Class II (genetics)
• Humans
• Molecular Sequence Data
• Odds Ratio
• Oligonucleotide Probes
• Polymerase Chain Reaction
• Time Factors