HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Antiemetic activity of oral lorazepam in addition to methylprednisolone and metoclopramide in the prophylactic treatment of vomiting induced by cisplatin. A double-blind, placebo-controlled study with crossover design.

AbstractAIMS AND BACKGROUND:
It has been suggested that lorazepam has a definite role as an antiemetic drug in antiemetic cocktails. In this study we examined the antiemetic efficacy of metoclopramide (200 mg) and methylprednisolone (1000 mg) with or without lorazepam.
METHODS:
Sixty patients treated with cisplatin-containing regimens were entered into a randomized, double-blind study with cross-over. Lorazepam 2.5 mg or placebo were administered orally the evening before therapy and just after the beginning of fluid infusion for chemotherapy. Degree of nausea and number of vomiting episodes, together with somnolence, were recorded on a data flow sheet and visual-analogue scales.
RESULTS:
100 cycles (50 patients) are evaluable. In 39 cycles there was no nausea and vomiting, in 74 cycles acceptable control of emesis was reached (0-2 episodes of vomiting), without significant differences among the two arms. However, nausea was shorter in lorazepam arm (p < 0.01), and 80% of the patients preferred treatment with lorazepam (p < 0.003). Anxiety was reduced in the patients treated with lorazepam (p < 0.4).
CONCLUSIONS:
Lorazepam improves tolerability to cisplatin-containing chemotherapy, mainly by influencing the psychological status of the patient and favoring the amnestic process.
AuthorsM Clerico, O Bertetto, M P Morandini, C Cardinali, G Giaccone
JournalTumori (Tumori) Vol. 79 Issue 2 Pg. 119-22 (Apr 30 1993) ISSN: 0300-8916 [Print] United States
PMID8346563 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Metoclopramide
  • Lorazepam
  • Cisplatin
  • Methylprednisolone
Topics
  • Adult
  • Aged
  • Cisplatin (adverse effects)
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Humans
  • Lorazepam (administration & dosage)
  • Male
  • Methylprednisolone (administration & dosage)
  • Metoclopramide (administration & dosage)
  • Middle Aged
  • Neoplasms (drug therapy)
  • Vomiting (chemically induced, prevention & control)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: