Direct application of basic fibroblast growth factor improves tympanic membrane perforation healing.

Abstract

Topical application of basic fibroblast growth factor (b-FGF) on tympanic membrane (TM) perforations was studied in guinea pigs. One-millimeter simple round TM perforations or 2-mm TM perforations with medially flapped borders were performed. Either b-FGF or placebo was instilled in each ear on the day of surgery and daily thereafter. Treatment was applied either directly to the perforation or to a Gelfoam pledget over the defect. When no scaffolding material was interposed, b-FGF induced a faster healing response characterized by a hyperplastic but linear subepidermal connective tissue reaction compared to the control. When Gelfoam was interposed as a scaffold, a voluminous scar protruding into the middle ear cavity and involving the ossicles was observed in both b-FGF and control animals. Gelfoam-induced scars did not decrease after long-term observation, therefore discouraging its use.

• Authors: M Fina, A Baird, A Ryan
• Journal: The Laryngoscope (Laryngoscope) Vol. 103 Issue 7 Pg. 804-9 (Jul 1993) ISSN: 0023-852X [Print] United States
• PMID: 8341107 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Fibroblast Growth Factor 2

Topics

• Animals
• Female
• Fibroblast Growth Factor 2 (therapeutic use)
• Guinea Pigs
• Tympanic Membrane (injuries, pathology)
• Wound Healing
• Wounds, Penetrating (drug therapy)