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Application of salivary concentration data to pharmacokinetic studies with antipyrine.

Abstract
The concentrations of antipyrine in plasma and saliva were equivalent in normal volunteers and in patients with acute viral hepatitis following oral doses of antipyrine. Estimates of clearance, volume of distribution, and half-life made from either plasma or saliva samples were not statistically different in these subjects. Differences in the disposition kinetics of anticted using either plasma or saliva samples.
AuthorsP J Meffin, R L Williams, T F Blaschke, M Rowland
JournalJournal of pharmaceutical sciences (J Pharm Sci) Vol. 66 Issue 1 Pg. 135-7 (Jan 1977) ISSN: 0022-3549 [Print] United States
PMID833730 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antipyrine
Topics
  • Acute Disease
  • Antipyrine (blood, metabolism)
  • Hepatitis, Viral, Human (metabolism)
  • Humans
  • Kinetics
  • Male
  • Saliva (metabolism)

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