Histocompatibility antigens and La Crosse encephalitis.

Abstract

Major histocompatibility complex antigens (HLA-ABC and -DR loci) on lymphocytes from 79 patients with La Crosse encephalitis were compared with those of 69 control subjects. Nine patients (11%) and none of the control population had HLA-B49 (P < .01, uncorrected for multiple comparisons). Of La Crosse encephalitis patients with acute-phase seizures, only 2 (7%) were positive for HLA-DR5, whereas 16 (37%) of nonseizure patients were positive for that antigen (P < .025). These findings suggest that susceptibility and complications associated with this disease may have an immunogenetic component.

• Authors: K L Case, R M West, M J Smith
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 168 Issue 2 Pg. 358-60 (Aug 1993) ISSN: 0022-1899 [Print] United States
• PMID: 8335971 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA Antigens
• HLA-DR Antigens

Topics

• Encephalitis Virus, California
• Encephalitis, California (immunology)
• HLA Antigens (immunology)
• HLA-DR Antigens (immunology)
• Humans