[Anti-ischemic therapy with verapamil. Improving prognosis by secondary prevention after acute myocardial infarct].

Abstract

Calcium antagonists reduce myocardial oxygen demand and increase the oxygen supply to the myocardium via a coronary dilating effect. For the treatment of silent myocardial ischämia and of stable and instable angina pectoris, studies with verapamil revealed an anti-ischemic efficacy comparable with that of beta blockers and nitrates. Studies of secondary prophylaxis after acute myocardial infarction reveal a cardioprotective effect of verapamil in terms of a reduction in mortality and re-infarction rates. Calcium antagonists have further organ-protective effects such as a reduction of left ventricular wall hypertrophy and a slowing effect on the progression of arteriosclerotic vascular changes.

• Authors: F Dotzer, H Gromer
• Journal: Fortschritte der Medizin (Fortschr Med) Vol. 111 Issue 14 Pg. 245-8 (May 20 1993) ISSN: 0015-8178 [Print] Germany
• Vernacular Title: Antiischämische Therapie mit Verapamil. Prognoseverbesserung durch Sekundärprophylaxe nach akutem Myokardinfarkt.
• PMID: 8335304 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Nitrates
• Verapamil

Topics

• Coronary Circulation (drug effects)
• Drug Therapy, Combination
• Humans
• Myocardial Infarction (drug therapy, mortality)
• Myocardial Ischemia (drug therapy, mortality)
• Nitrates (therapeutic use)
• Prognosis
• Verapamil (adverse effects, therapeutic use)