Abstract | BACKGROUND: METHODS: RESULTS: Placebo and tin protoporphyrin alone had little effect on ALA and PBG excretion. Following heme arginate alone or combined with tin protoporphyrin, there was a marked and similar suppression of both ALA and PBG excretion (P < 0.005 for each, compared with pretreatment values). However, on the 5th day after discontinuing treatment, the excretion of ALA and PBG were both lower following combination therapy than following heme arginate alone (P < 0.005 and P < 0.01, respectively). CONCLUSIONS:
|
Authors | S B Dover, M R Moore, E J Fitzsimmons, A Graham, K E McColl |
Journal | Gastroenterology
(Gastroenterology)
Vol. 105
Issue 2
Pg. 500-6
(Aug 1993)
ISSN: 0016-5085 [Print] United States |
PMID | 8335204
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Metalloporphyrins
- Protoporphyrins
- Heme
- Arginine
- tin protoporphyrin IX
- heme arginate
|
Topics |
- Acute Disease
- Adult
- Arginine
(adverse effects, therapeutic use)
- Drug Synergism
- Drug Therapy, Combination
- Female
- Heme
(adverse effects, therapeutic use)
- Humans
- Male
- Metalloporphyrins
(adverse effects, therapeutic use)
- Porphyrias, Hepatic
(drug therapy, metabolism)
- Protoporphyrins
(adverse effects, therapeutic use)
|