Abstract | BACKGROUND: METHODS: We studied 57 pregnancies of 41 women with rheumatoid arthritis, 18 prospectively and 39 retrospectively. Serologic and DNA techniques were used to study HLA class I and II antigens. For newborns, typing was performed from cord-blood samples obtained at delivery. For four young children, typing was performed from DNA extracted from hair samples. RESULTS: We found significantly more maternal-fetal disparity in HLA-DR and DQ antigens in pregnancies characterized by the remission or improvement of rheumatoid arthritis than in pregnancies characterized by active disease. Further studies using DNA-typing techniques to define allelic variants of HLA-DR and DQ antigens confirmed this observation. Maternal-fetal disparity in alleles of HLA- DRB1, DQA, and DQB occurred in 26 of 34 pregnancies characterized by remission or improvement (76 percent), as compared with 3 of 12 pregnancies characterized by active arthritis (25 percent) (odds ratio, 9.7; P = 0.003). The difference between the two groups was most marked for alleles of HLA-DQA. CONCLUSIONS:
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Authors | J L Nelson, K A Hughes, A G Smith, B B Nisperos, A M Branchaud, J A Hansen |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 329
Issue 7
Pg. 466-71
(Aug 12 1993)
ISSN: 0028-4793 [Print] United States |
PMID | 8332151
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- HLA Antigens
- HLA-DQ Antigens
- HLA-DR Antigens
- Histocompatibility Antigens Class II
- Isoantigens
- DNA
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Topics |
- Alleles
- Arthritis, Rheumatoid
(immunology)
- DNA
- Female
- Fetal Blood
(immunology)
- Fetus
(immunology)
- HLA Antigens
(blood, genetics)
- HLA-DQ Antigens
(blood, genetics)
- HLA-DR Antigens
(blood, genetics)
- Histocompatibility Antigens Class II
(blood, genetics)
- Humans
- Infant, Newborn
- Isoantigens
(immunology)
- Odds Ratio
- Pregnancy
- Pregnancy Complications
(immunology)
- Prospective Studies
- Retrospective Studies
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