Abstract |
The expression of fragile sites induced by aphidicolin (APC) was evaluated on metaphase chromosomes obtained from the peripheral blood lymphocytes of 26 women with breast cancer and 15 sex- and age-matched normal controls. Both the proportion of damaged cells (P < 0.001) and the mean number of gaps and breaks per cell (0.02 < P < 0.05) were significantly higher in the patient group. There were no differences in either the age-related fragile site levels or the expression of single fragile sites between patients and controls. Our findings indicate an increased genetic instability in women with breast carcinoma.
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Authors | C Ardisia, G Venti, M A Colozza, C Breschi, B Porfirio, S Davis, M Tonato, E Donti |
Journal | Cancer genetics and cytogenetics
(Cancer Genet Cytogenet)
Vol. 67
Issue 2
Pg. 113-6
(Jun 1993)
ISSN: 0165-4608 [Print] United States |
PMID | 8330266
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Age Factors
- Aged
- Aphidicolin
(pharmacology)
- Breast Neoplasms
(genetics)
- Cells, Cultured
- Chromosome Fragile Sites
- Chromosome Fragility
- Female
- Humans
- Lymphocytes
(ultrastructure)
- Middle Aged
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