[A comparison of the effects of haloperidol when administered systemically and injected into the striatum of rats].

Abstract

The effects of chronic intraperitoneal (2 mg/kg) and bilaterally intrastriatal (5 micrograms) haloperidol were studied in albino male rats. Intraperitoneal injections resulted in inhibition of conditioned avoidance reflexes and catalepsy. After intrastriatal microinjections, the Parkinsonism-like status appeared along with akinesia and rigidity; that effect was recorded on day 7 of the experiment, which lasted up to the first few days of haloperidol withdrawal. The causes of distinctions between the effects of systemic and local intrastriatal haloperidol injections are discussed.

• Authors: A F Iakimovskiĭ
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1993 Jan-Feb Vol. 56 Issue 1 Pg. 11-3 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Sravnenie éffektov galoperidola pri sistemnom vvedenii i in''ektsii v striatum u krys.
• PMID: 8324466 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Haloperidol

Topics

• Animals
• Avoidance Learning (drug effects)
• Catalepsy (chemically induced)
• Conditioning, Classical (drug effects)
• Corpus Striatum
• Electric Stimulation
• Haloperidol (administration & dosage, pharmacology)
• Injections, Intraperitoneal
• Male
• Microinjections (methods)
• Muscle Rigidity (chemically induced)
• Rats
• Time Factors