Combined dialysis and plasma-exchange in acute renal failure.

Abstract

Combined use of plasma-exchange and dialysis therapy in 3 different cases of acute renal failure is presented. The first is a case of acute renal failure due to rhabdomyolysis caused by hemlock poisoning. Plasma-exchange was effective in improving the signs of rhabdomyolysis and renal failure. The second is a case of acute renal failure in an IgG-kappa myeloma. After 9 sessions of plasma-exchange, performed simultaneously with CAPD, a significant fall in the plasma and urine light chains levels was obtained. After the recovery of normal renal function, CAPD was prosecuted to remove light chains. The last is a case of acute renal failure in a patient with a mesangiocapillary nephritis and a high level of circulating immune complexes (CIC). He underwent steroid therapy and daily sessions of hemodialysis, followed by plasma-exchange, which permitted a fall of the CIC level, until a normal renal function was achieved. In conclusion, plasma-exchange combined with dialysis, is an useful tool for the management of acute renal failure caused by toxic proteins.

• Authors: N E Montemurro, A Di Maggio, P Strippoli, F Coviello, F Godino, G Miloro, A Scatizzi
• Journal: Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology (Biomater Artif Cells Immobilization Biotechnol) Vol. 21 Issue 2 Pg. 283-7 ( 1993) ISSN: 1055-7172 [Print] United States
• PMID: 8318619 (Publication Type: Case Reports, Journal Article)

Chemical References

• Blood Proteins

Topics

• Acute Kidney Injury (blood, etiology, therapy)
• Adult
• Blood Component Removal
• Blood Proteins (isolation & purification)
• Combined Modality Therapy
• Female
• Humans
• Male
• Middle Aged
• Oliguria (complications)
• Plasma Exchange
• Renal Dialysis