[Diagnostic and predictive importance of the blast transformation test and basophil activation test in retinal vasculitis].

Abstract

22 patients suffering from Birdshot retinochoroidopathy (10), idiopathic vasculitis (6) and Behcet disease (6) and treated by cyclosporine were tested at regular intervals during 11 to 38 months by the lymphocyte stimulation test (LST) and basophil degranulation test (HBDT) with S retinal antigen. These two tests were found frequently positive especially during acute inflammation for the LST. However HBDT was positive in all the patients before relapse of acute inflammation which is in favor of its predictive value and its involvement in the triggering of inflammation at the basophiles or at the local mast cell level.

• Authors: J Sainte-Laudy, D Jobin, B Thillaye, Y de Kozak, J P Faure, P Le Hoang
• Journal: Allergie et immunologie (Allerg Immunol (Paris)) Vol. 25 Issue 3 Pg. 103-5 (Mar 1993) ISSN: 0397-9148 [Print] France
• Vernacular Title: Intérêt diagnostique et prédictif du test de transformation blastique et du test d'activation des basophiles au cours des vascularites rétiniennes.
• PMID: 8318138 (Publication Type: Comparative Study, English Abstract, Journal Article)

Topics

• Basophil Degranulation Test
• Behcet Syndrome (diagnosis, immunology)
• Chorioretinitis (diagnosis, immunology)
• Humans
• Lymphocyte Activation
• Predictive Value of Tests
• Retinitis (diagnosis, immunology)
• Vasculitis (diagnosis, immunology)