New electron microscopic findings in a case of multicentric reticulohistiocytosis. Long spacing collagen inclusions.

Abstract

The case of a 68-year-old woman with polyarthropathy and skin nodules is presented. Histologic findings of histiocytes with ground-glass cytoplasm favored the diagnosis of multicentric reticulohistiocytosis. In this article we report new electron microscopic findings of intra- and extracytoplasmic long spacing collagen (type VI). Type VI collagen inclusions are usually found in lymphohistiocytic neoplasms. We believe our findings support the concept of a proliferative rather than inflammatory etiology for multicentric reticulohistiocytosis. It may also give support for the argument of production of collagen by the histiocytic cells of multicentric reticulohistiocytosis.

• Authors: M Fortier-Beaulieu, E Thomine, M C Boullie, X Le Loët, P Lauret, J Hemet
• Journal: The American Journal of dermatopathology (Am J Dermatopathol) Vol. 15 Issue 6 Pg. 587-9 (Dec 1993) ISSN: 0193-1091 [Print] United States
• PMID: 8311193 (Publication Type: Case Reports, Journal Article)

Chemical References

• Collagen

Topics

• Aged
• Collagen (ultrastructure)
• Female
• Histiocytosis, Non-Langerhans-Cell (pathology)
• Humans
• Skin (ultrastructure)
• Skin Diseases (pathology)