Long-term effects of postnatal hypoxia and flunarizine on the dopaminergic system.

Abstract

Long-term changes of learning behavior and of the striatal dopaminergic system were observed in a rat model of early postnatal hypoxia. Striatal dopamine (DA) concentration, K(+)-stimulated DA release from slices, and DA uptake into crude synaptosomal preparations (S1 fractions) were used as markers of the striatal DAergic system. Active avoidance learning was tested as behavioral criterion. Cyclodextrin and flunarizine were found to produce long-term effects on the DAergic system in control animals. While cyclodextrin normalized hypoxia-induced effects in DA release, flunarizine prevented those in DA uptake and improved avoidance learning.

• Authors: A Lun, C Berndt, J Gross, H D Fischer, E Bergsträsser, D Scheller
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 46 Issue 4 Pg. 867-71 (Dec 1993) ISSN: 0091-3057 [Print] United States
• PMID: 8309967 (Publication Type: Journal Article)

Chemical References

• Catecholamines
• 3,4-Dihydroxyphenylacetic Acid
• Flunarizine
• Dopamine
• Homovanillic Acid

Topics

• 3,4-Dihydroxyphenylacetic Acid (metabolism)
• Animals
• Avoidance Learning (drug effects)
• Catecholamines (metabolism)
• Dopamine (metabolism, physiology)
• Flunarizine (pharmacology)
• Homovanillic Acid (metabolism)
• Hypoxia (physiopathology)
• In Vitro Techniques
• Kinetics
• Male
• Neostriatum (drug effects, metabolism)
• Rats
• Rats, Wistar
• Synaptosomes (drug effects, metabolism)