Bleeding peptic ulcer: pathogenesis and endoscopic therapy.

Abstract

The presence of stigmata of hemorrhage in a peptic ulcer indicate an increased risk of rebleeding and the need for endoscopic intervention. Clinical trials indicate that laser photocoagulation, multipolar and heater probe coagulation, and injection therapy are all effective in decreasing bleeding from peptic ulcer disease. The modality used for the individual patient depends on available resources and the experience of the endoscopist. Laser photocoagulation is used infrequently, not because of a lack of efficacy but because of its increased cost and impracticality, including its lack of portability. Multipolar coagulation and heater probe coagulation are commonly employed but may give way to injection therapy as first-line therapy, because it is equally effective, cost less, and is easy to implement in a variety of clinical settings.

• Authors: G Zuccaro Jr
• Journal: Gastroenterology clinics of North America (Gastroenterol Clin North Am) Vol. 22 Issue 4 Pg. 737-50 (Dec 1993) ISSN: 0889-8553 [Print] United States
• PMID: 8307640 (Publication Type: Comparative Study, Journal Article, Review)

Chemical References

• Vasoconstrictor Agents

Topics

• Clinical Trials as Topic
• Duodenal Ulcer (complications)
• Endoscopy, Gastrointestinal
• Hemostasis, Endoscopic
• Humans
• Injections
• Laser Coagulation
• Light Coagulation
• Peptic Ulcer Hemorrhage (diagnosis, etiology, physiopathology, therapy)
• Randomized Controlled Trials as Topic
• Recurrence
• Risk Factors
• Stomach Ulcer (complications)
• Vasoconstrictor Agents (therapeutic use)