Correlation between DNA ploidy and clinical features in smooth muscle tumors of the gastrointestinal tract.

Abstract

Paraffin-embedded tissue samples from 51 surgically resected, gastrointestinal smooth muscle tumors (10 leiomyomas, 5 leiomyoblastomas and 36 leiomyosarcomas) were assayed for nuclear DNA content, and the results were examined for correlation with clinico-pathological variables (tumor size, cellularity and mitosis) and prognosis. Twenty-four (47%) of the 51 tumors, consisting of 3 (30%) of the 10 leiomyomas, 2 (40%) of the 5 leiomyoblastomas and 19 (53%) of the 36 leiomyosarcomas, were identified as aneuploid. A close correlation was found between the mitotic index and the tumor size (<cc> = 0.528; P < 0.001). The DNA ploidy pattern of the leiomyosarcoma was closely correlated with the patient survival periods (P = 0.06). The estimated median survival period was 73 months for patients with diploid tumors, and 51 months for those with aneuploid tumors. The 10-year survival rate for aneuploid tumors was lower than that for diploid tumors (P < 0.001). The measurement of DNA content may provide an index of prognostic value in gastrointestinal leiomyosarcomas.

• Authors: H Kimura, Y Yonemura, N Kadoya, T Kosaka, K Miwa, I Miyazaki, T Sawa, S Yoshimitsu, Y Nishida, T Kamata
• Journal: Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology (Anal Cell Pathol) Vol. 5 Issue 6 Pg. 331-8 (Nov 1993) ISSN: 0921-8912 [Print] Netherlands
• PMID: 8305329 (Publication Type: Journal Article)

Chemical References

• DNA, Neoplasm

Topics

• Adult
• Aged
• DNA, Neoplasm (analysis, genetics)
• Female
• Gastrointestinal Neoplasms (genetics, pathology)
• Humans
• Leiomyoma (genetics, pathology)
• Leiomyoma, Epithelioid (genetics, pathology)
• Leiomyosarcoma (genetics, pathology)
• Male
• Middle Aged
• Muscle, Smooth
• Ploidies