High-dose tocopherol acetate therapy in epidermolysis bullosa siblings of the Cockayne-Touraine type.

Abstract

We have employed a successful therapy for epidermolysis bullosa with high-dose oral tocopherol acetate. Two siblings with dominant dystrophic epidermolysis bullosa of the Cockayne-Touraine type were reported. Both siblings suffered from tense blisters and erosions healing with scars and transient milia on the extremities. Electron microscopic study of the blisters revealed a cleavage beneath the lamina densa in both siblings. High-dose oral tocopherol acetate therapy was administered to them with satisfactory clinical reduction of the blister formation.

• Authors: Y Shirakata, S Shiraishi, K Sayama, H Shinmori, Y Miki
• Journal: The Journal of dermatology (J Dermatol) Vol. 20 Issue 11 Pg. 723-5 (Nov 1993) ISSN: 0385-2407 [Print] England
• PMID: 8300945 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Vitamin E
• alpha-Tocopherol
• Tocopherols

Topics

• Epidermolysis Bullosa Dystrophica (drug therapy, genetics, pathology)
• Humans
• Infant
• Male
• Tocopherols
• Vitamin E (administration & dosage, analogs & derivatives)
• alpha-Tocopherol (analogs & derivatives)