HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of a sodium benzoate-sodium bicarbonate compound on dental plaque formation.

Abstract
The objective of this study was to evaluate the effect of a sodium benzoate-sodium bicarbonate (SBSB) compound on dental plaque formation and developing gingivitis. Eighteen subjects were given a prophylaxis and instruction in oral hygiene to establish plaque-free conditions and gingival health for the study baseline. They were randomly divided into three groups. Each participant was instructed to rinse twice daily with either a 0.15% chlorhexidine digluconate solution, the SBSB compound, or a placebo solution for 21 days. They refrained from all other oral hygiene procedures during this period. Plaque, gingival, and stain indices were scored at baseline and at days 7, 14, and 21 during the rinsing protocol. A significant increase in plaque accumulation was observed for the SBSB compound and placebo groups in days 7 through 21. No increase in plaque accumulation was observed in the chlorhexidine group. An increase in gingival inflammation was observed in all groups, with no significant differences between groups. Significant increases in gingival bleeding occurrence compared to baseline were found in the chlorhexidine group by day 21, in the SBSB compound group by day 7, and in the placebo group by day 14. The present study did not disclose any plaque or gingivitis inhibiting effects of the SBSB compound.
AuthorsD Ozanich, L Winn, N A Medina, U M Wikesjö, P Nygaard-Ostby
JournalJournal of periodontology (J Periodontol) Vol. 64 Issue 11 Pg. 1067-70 (Nov 1993) ISSN: 0022-3492 [Print] United States
PMID8295092 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Benzoates
  • Sodium Bicarbonate
  • Benzoic Acid
  • Chlorhexidine
Topics
  • Adult
  • Analysis of Variance
  • Benzoates (therapeutic use)
  • Benzoic Acid
  • Chlorhexidine (therapeutic use)
  • Dental Plaque (prevention & control)
  • Double-Blind Method
  • Female
  • Gingivitis (prevention & control)
  • Humans
  • Male
  • Sodium Bicarbonate (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: