Abstract | OBJECTIVES: BACKGROUND: METHODS: Isolated "working" guinea pig hearts and phosphorus-31 nuclear magnetic resonance spectroscopy were used to study the recovery of myocardial function and phosphorus compounds after 30, 40 and 50 min of normothermic global ischemia followed by reperfusion in untreated control and glibenclamide- and cromakalim-treated groups. RESULTS: After 30 min of ischemia, 1, 3, 10 and 30 mumol/liter of glibenclamide dose-dependently reduced the incidence of reperfusion-induced ventricular fibrillation (total) from its control value of 92% to 75%, 33% (p < 0.05), 33% (p < 0.05) and 42% (p < 0.05), respectively. The incidence of ventricular tachycardia followed the same pattern. A reduction of arrhythmias was also observed after 40 and 50 min of ischemia followed by reperfusion in the glibenclamide-treated hearts. Cromakalim, at the same concentrations, did not reduce the incidence of reperfusion-induced arrhythmias. During reperfusion, glibenclamide (3 and 10 mumol/liter) improved the recovery of coronary blood flow, aortic flow, myocardial contractility and tissue ATP and creatine phosphate content, but cromakalim failed to ameliorate the recovery of postischemic myocardium compared with that in the drug-free control hearts. CONCLUSIONS:
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Authors | A Tosaki, A Hellegouarch |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 23
Issue 2
Pg. 487-96
(Feb 1994)
ISSN: 0735-1097 [Print] United States |
PMID | 8294705
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Arrhythmia Agents
- Antihypertensive Agents
- Benzopyrans
- Potassium Channels
- Pyrroles
- Cromakalim
- Adenosine Triphosphate
- Glyburide
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Topics |
- Adenosine Triphosphate
(physiology)
- Animals
- Anti-Arrhythmia Agents
(pharmacology)
- Antihypertensive Agents
(pharmacology)
- Benzopyrans
(pharmacology)
- Cromakalim
- Dose-Response Relationship, Drug
- Glyburide
(pharmacology)
- Guinea Pigs
- Magnetic Resonance Spectroscopy
- Male
- Myocardial Reperfusion Injury
(physiopathology, prevention & control)
- Myocardium
(metabolism)
- Potassium Channels
(drug effects, physiology)
- Pyrroles
(pharmacology)
- Tachycardia, Ventricular
(physiopathology, prevention & control)
- Ventricular Fibrillation
(physiopathology, prevention & control)
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