HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Intravenous corticosteroids versus intravenous gammaglobulin in the treatment of acute immune thrombocytopenic purpura.

Abstract
Debate continues over the most appropriate treatment for children with acute immune thrombocytopenic purpura (ITP). An institutional review of all admissions for acute ITP between 1986 and 1991 found 61 children treated with intravenous (i.v.) IgG or i.v. steroids with a bone marrow aspirate consistent with ITP, an age of 21 years or younger, and an admission platelet count of < or = 20,000/mm3. The efficacy of these two agents was compared in the described population. A response was defined as achieving a platelet count of > or = 50,000/mm3. A significantly greater percentage of patients responded to i.v. IgG compared to i.v. steroids during the first 36 hr of therapy; however, by 72 hr of treatment there was no significant difference. The cost of hospitalization was 3 1/2 times greater for the patients responding to i.v. IgG vs. i.v. steroids.
AuthorsJ D Hord, N J Grossman
JournalPediatric hematology and oncology (Pediatr Hematol Oncol) 1993 Oct-Dec Vol. 10 Issue 4 Pg. 323-7 ISSN: 0888-0018 [Print] England
PMID8292516 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Adrenal Cortex Hormones
  • Immunoglobulins, Intravenous
Topics
  • Acute Disease
  • Adrenal Cortex Hormones (administration & dosage, therapeutic use)
  • Child
  • Child, Preschool
  • Female
  • Health Care Costs
  • Hospitalization (economics)
  • Humans
  • Immunoglobulins, Intravenous (therapeutic use)
  • Injections, Intravenous
  • Male
  • Purpura, Thrombocytopenic, Idiopathic (therapy)
  • Retrospective Studies

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: