Abstract |
Debate continues over the most appropriate treatment for children with acute immune thrombocytopenic purpura ( ITP). An institutional review of all admissions for acute ITP between 1986 and 1991 found 61 children treated with intravenous (i.v.) IgG or i.v. steroids with a bone marrow aspirate consistent with ITP, an age of 21 years or younger, and an admission platelet count of < or = 20,000/mm3. The efficacy of these two agents was compared in the described population. A response was defined as achieving a platelet count of > or = 50,000/mm3. A significantly greater percentage of patients responded to i.v. IgG compared to i.v. steroids during the first 36 hr of therapy; however, by 72 hr of treatment there was no significant difference. The cost of hospitalization was 3 1/2 times greater for the patients responding to i.v. IgG vs. i.v. steroids.
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Authors | J D Hord, N J Grossman |
Journal | Pediatric hematology and oncology
(Pediatr Hematol Oncol)
1993 Oct-Dec
Vol. 10
Issue 4
Pg. 323-7
ISSN: 0888-0018 [Print] England |
PMID | 8292516
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Adrenal Cortex Hormones
- Immunoglobulins, Intravenous
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Topics |
- Acute Disease
- Adrenal Cortex Hormones
(administration & dosage, therapeutic use)
- Child
- Child, Preschool
- Female
- Health Care Costs
- Hospitalization
(economics)
- Humans
- Immunoglobulins, Intravenous
(therapeutic use)
- Injections, Intravenous
- Male
- Purpura, Thrombocytopenic, Idiopathic
(therapy)
- Retrospective Studies
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