Abstract | BACKGROUND:
Barbiturates are reported to reduce brain oxidative metabolism and brain free fatty acid release during ischemia by mechanisms that are as yet unclear. To elucidate their action on brain lipid metabolism, an in vivo method was used to quantify the effect of pentobarbital on the incorporation of radiolabeled palmitic acid from blood into lipids of the rat brain. METHODS: [9,10(-3)H]- Palmitate was infused intravenously in an awake rat or in a rat lightly anesthetized or made comatose by pentobarbital. Twenty minutes after infusion was begun, the rat was killed and non-3H2O radioactivity in individual brain lipid compartments was determined. Incorporation coefficients (k*) were calculated by dividing the lipid compartment radioactivities by the integrated plasma radioactivity to 20 min. RESULTS: CONCLUSIONS:
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Authors | S Yamazaki, J J DeGeorge, J M Bell, S I Rapoport |
Journal | Anesthesiology
(Anesthesiology)
Vol. 80
Issue 1
Pg. 151-8
(Jan 1994)
ISSN: 0003-3022 [Print] United States |
PMID | 8291704
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Brain
(drug effects, metabolism)
- Male
- Palmitates
(blood, pharmacokinetics)
- Pentobarbital
(pharmacology)
- Rats
- Rats, Inbred F344
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