A controlled comparison of the effects of propranolol, benztropine, and placebo on akathisia: an interim analysis.

Abstract

A group of 28 patients was treated to compare the effects on akathisia of the following: propranolol (80 mg/day), benztropine (6 mg/day), or placebo. Both propranolol and benztropine significantly improved akathisia by Day 3-5 of treatment. Placebo had no significant effects of akathisia. Three patients developed confusion or forgetfulness by Day 3 of benztropine treatment; these effects cleared upon discontinuation of benztropine.

• Authors: L A Adler, E Peselow, M Rosenthal, B Angrist
• Journal: Psychopharmacology bulletin (Psychopharmacol Bull) Vol. 29 Issue 2 Pg. 283-6 ( 1993) ISSN: 0048-5764 [Print] United States
• PMID: 8290678 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Benztropine
• Propranolol

Topics

• Adult
• Aged
• Akathisia, Drug-Induced (drug therapy)
• Benztropine (adverse effects, therapeutic use)
• Humans
• Middle Aged
• Propranolol (adverse effects, therapeutic use)
• Single-Blind Method