Abstract |
Total plasma lactate dehydrogenase (LDH) activity may be elevated in cryptogenic fibrosing alveolitis (CFA) and extrinsic allergic alveolitis (EAA), and may be a useful monitor of disease progress. In a retrospective, primary referral centre study, we compared LDH at presentation, prior to bronchoalveolar lavage BAL, and after treatment and follow-up with changes in pulmonary function, in patients with CFA, EAA and pulmonary sarcoidosis. Plasma levels of LDH at presentation in CFA (n = 47) and EAA (n = 10) were significantly higher than in patients with sarcoidosis (n = 36). LDH activity decreased in patients with improving lung function (EAA, p = 0.008; CFA, p = 0.02), whereas it increased in CFA patients with deteriorating lung function (p = 0.015). Total plasma LDH is a simple, though nonspecific test, which appears to reflect changes of disease activity in patients with CFA and EAA.
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Authors | S P Matusiewicz, I J Williamson, P J Sime, P H Brown, P R Wenham, G K Crompton, A P Greening |
Journal | The European respiratory journal
(Eur Respir J)
Vol. 6
Issue 9
Pg. 1282-6
(Oct 1993)
ISSN: 0903-1936 [Print] England |
PMID | 8287944
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- L-Lactate Dehydrogenase
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Alveolitis, Extrinsic Allergic
(diagnosis, physiopathology)
- Biomarkers
(blood)
- Follow-Up Studies
- Humans
- L-Lactate Dehydrogenase
(blood)
- Lung
(physiopathology)
- Lung Volume Measurements
- Male
- Middle Aged
- Pulmonary Fibrosis
(diagnosis, physiopathology)
- Retrospective Studies
- Sarcoidosis, Pulmonary
(diagnosis, physiopathology)
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