[Clinical evaluation of calcium-polycarbophil in the treatment of non-specific diarrhea].

Abstract

We performed a study on 10 patients aged between 26 and 54 males and females, affected by non-specific diarrhea. A single-blind clinical trial has been developed where Calcium-Polycarbophil was administered (2 cps t.i.d.) for a period of 8 weeks, half with placebo and half with drug in cross-over. No drop-out occurred. Number of evaluations, cramps and consistency of stools, have been evaluated before and after treatment. A definite decrease of evacuations per day and of cramps, when present, together with a higher consistency of stools, are reported when Calcium-Polycarbophil is administered, according to the favourable medical judgement. Haematochemical parameters, evaluated before, during and after the treatment didn't show any relevant variation, apart from slight increase (not statistically significant) of calcium both in blood and in urine). No other unwanted event has been detected. Hence, the high therapeutic index of Calcium-Polycarbophil makes it highly desirable in the treatment of diarrhea.

• Authors: G Gizzi, V Villani, M P Rubinetto, M Cianci, A La Froscia, L Barbara
• Journal: Minerva gastroenterologica e dietologica (Minerva Gastroenterol Dietol) Vol. 39 Issue 3 Pg. 139-43 (Sep 1993) ISSN: 1121-421X [Print] Italy
• Vernacular Title: Valutazione clinica del calcio-policarbofilico nella terapia delle diarree non specifiche.
• PMID: 8286486 (Publication Type: Clinical Trial, Clinical Trial, Phase III, Journal Article)

Chemical References

• Acrylic Resins
• Antidiarrheals
• calcium polycarbophil

Topics

• Acrylic Resins (therapeutic use)
• Adult
• Antidiarrheals (therapeutic use)
• Diarrhea (drug therapy)
• Female
• Humans
• Male
• Middle Aged
• Single-Blind Method
• Treatment Outcome