Hepatocellular adenoma in glycogen storage disease type IV.

Abstract

The development of hepatocellular adenoma has been recognized in association with glycogen storage disease type I and, less often, with glycogen storage disease type III, but, to our knowledge, it has not been reported in glycogen storage disease type IV. We had the opportunity to study an 11-month-old male infant who underwent orthotopic liver transplantation for cirrhosis that developed in the setting of glycogen storage disease type IV. A clinically unsuspected hepatocellular adenoma was present in the explanted liver. Glycogen storage disease type IV should be considered as a potential precursor to the development of hepatocellular adenoma. Recognition of this association is important, both in terms of the differential diagnosis of tumors that occur in this setting and also to anticipate potential complications of this benign neoplasm.

• Authors: N S Alshak, J Cocjin, L Podesta, R van de Velde, L Makowka, P Rosenthal, S A Geller
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 118 Issue 1 Pg. 88-91 (Jan 1994) ISSN: 0003-9985 [Print] United States
• PMID: 8285839 (Publication Type: Case Reports, Journal Article)

Topics

• Adenoma, Liver Cell (etiology, pathology)
• Biopsy
• Glycogen Storage Disease Type IV (complications)
• Humans
• Infant
• Liver (pathology)
• Liver Neoplasms (etiology, pathology)
• Male