A dose titration, and an open 6-week efficacy and safety study of desmopressin tablets in the management of nocturnal enuresis.

Abstract

The efficacy and safety of 6 weeks of treatment with desmopressin tablets at doses of 200 to 400 micrograms.at bedtime were investigated in 33 children with monosymptomatic nocturnal enuresis. During an initial 1 to 2-week dose titration period 22 patients (67%) became either completely dry or showed improvement, 7 (21%) showed no response and 4 (12%) dropped out of therapy. During tablet treatment 17 patients on 400 micrograms.and 5 on 200 micrograms.at bedtime increased the number of weekly dry nights from 2.0 +/- 1.6 (standard deviation) during a 2-week observation period to 5.2 +/- 1.9 (p < 0.001). During a subsequent 2-week period 40 micrograms.intranasal desmopressin showed a similar overall efficacy, with a mean of 5.4 +/- 1.6 dry nights per week. In addition, intranasal treatment was able to increase the number of dry nights in 2 of the 7 nonresponders to tablet treatment.

• Authors: T B Matthiesen, S Rittig, J C Djurhuus, J P Nørgaard
• Journal: The Journal of urology (J Urol) Vol. 151 Issue 2 Pg. 460-3 (Feb 1994) ISSN: 0022-5347 [Print] United States
• PMID: 8283560 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Deamino Arginine Vasopressin

Topics

• Administration, Intranasal
• Administration, Oral
• Adolescent
• Analysis of Variance
• Child
• Deamino Arginine Vasopressin (administration & dosage, therapeutic use)
• Enuresis (drug therapy)
• Female
• Follow-Up Studies
• Humans
• Male