Aneurysmal dilatation of ductus arteriosus during lipo-prostaglandin E1 therapy for diaphragmatic hernia.

Abstract

We report a case of congenital diaphragmatic hernia in which aneurysmal dilatation of ductus arteriosus developed after lipo-prostaglandin E1 (PGE1) therapy for persistent fetal circulation. After surgery Lipo-PGE1 was used at a dosage of 5 ng/kg per minute from days 2-9 during which aneurysmal dilatation (7 mm in diameter) developed and remained thereafter. Ductus arteriosus ligation was then performed. Lipo-PGE1 may promote ductus arteriosus dilatation in cases of persistent fetal circulation.

• Authors: M Tohyama, A Baba, T Tsuno, K Aonuma, A Komiyama
• Journal: European journal of pediatrics (Eur J Pediatr) Vol. 152 Issue 11 Pg. 877-9 (Nov 1993) ISSN: 0340-6199 [Print] Germany
• PMID: 8276014 (Publication Type: Case Reports, Journal Article)

Chemical References

• Alprostadil

Topics

• Alprostadil (therapeutic use)
• Aneurysm (etiology, surgery)
• Diaphragmatic Eventration (complications, surgery)
• Ductus Arteriosus
• Humans
• Infant, Newborn
• Male
• Persistent Fetal Circulation Syndrome (complications, drug therapy)
• Sutures