Regional distribution of diazepam and its metabolites in the brain of cat after chronic treatment.

Abstract

Repeated administration of diazepam leads to remarkable accumulation of N-desmethyldiazepam in white matter structures and in subcortical areas such as thalamus, hypothalamus, and hypophysis. Diazepam and the hydroxylated metabolites were present in lesser amounts. The distribution pattern of diazepam and N-desmethyldiazepam offers a rationale for its efficacy in inhibiting seizures spreading and for the lack of effect on primary foci discharges.

• Authors: G F Placidi, G Tognoni, G M Pacifici, G B Cassano, P L Morselli
• Journal: Psychopharmacology (Psychopharmacology (Berl)) Vol. 48 Issue 2 Pg. 133-7 (Jul 28 1976) ISSN: 0033-3158 [Print] Germany
• PMID: 826924 (Publication Type: Journal Article)

Chemical References

• Oxazepam
• Diazepam

Topics

• Animals
• Brain (metabolism)
• Cats
• Cerebral Cortex (metabolism)
• Diazepam (metabolism)
• Oxazepam (metabolism)