Genetic predisposition and IDDM in Greece.

Abstract

Serological typing of HLA-DR antigens was performed on 116 patients with IDDM and 380 healthy controls. As expected a high incidence of HLA-DR3 and DR4 antigens was observed in patients with IDDM. However, the HLA-DR2 antigen, which rarely occurs in IDDM and is considered to confer protection against IDDM, was found in equal distribution (35%) in both patients and controls. HLA-DQ genotype analysis in 10 children with IDDM and 13 controls, all with the HLA-DR2 haplotype, showed that the great majority of affected children and normal controls carry the DR2 (16) or AZH-DQA1 *0102, DQB *0502 subtype. The high incidence of this subtype in normal individuals possibly explains why the DR2 antigen does not offer protection against IDDM in Greeks.

• Authors: C Karayanni, V Anastasiadou, M Spyropoulou, D Delis, I Khalil, V Lepage, M Papanicolaoy, M Varla, A Stavropoulou, C S Bartsocas
• Journal: Genetic counseling (Geneva, Switzerland) (Genet Couns) Vol. 4 Issue 3 Pg. 181-6 ( 1993) ISSN: 1015-8146 [Print] Switzerland
• PMID: 8267924 (Publication Type: Journal Article)

Chemical References

• HLA-DQ Antigens
• HLA-DR Antigens

Topics

• Adolescent
• Alleles
• Child
• Child, Preschool
• Diabetes Mellitus, Type 1 (genetics, immunology)
• Female
• Gene Frequency
• Genes, MHC Class II
• Genotype
• Greece
• HLA-DQ Antigens (blood, genetics)
• HLA-DR Antigens (blood, genetics)
• Humans
• Infant
• Male