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Intra-hippocampal injection of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) inhibits partial and generalized seizures induced by kindling stimulation in cats.

Abstract
This study assessed the effects of microinjections of a serotonin (5-HT) 1A agonist, 8-OH-DPAT, into the feline hippocampus (HIP) on seizure response induced by electrical stimulation of this region. Intra-HIP injection of 8-OH-DPAT (10 nmol) produced a significant elevation in the afterdischarge threshold of partial HIP seizures, with a significant reduction in the duration of focal afterdischarge. Similarly, microinjection of 8-OH-DPAT at the same dose significantly raised the seizure threshold for eliciting generalized seizures in HIP-kindled cats. The present results demonstrate that focally applied 8-OH-DPAT possesses a potent anticonvulsant action, and provide further evidence for the inhibitory role of 5-HT1A receptors in the generation of HIP seizures.
AuthorsY Wada, M Nakamura, H Hasegawa, N Yamaguchi
JournalNeuroscience letters (Neurosci Lett) Vol. 159 Issue 1-2 Pg. 179-82 (Sep 03 1993) ISSN: 0304-3940 [Print] Ireland
PMID8264964 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anticonvulsants
  • Receptors, Serotonin
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
Topics
  • 8-Hydroxy-2-(di-n-propylamino)tetralin (administration & dosage, pharmacology)
  • Animals
  • Anticonvulsants (administration & dosage, pharmacology)
  • Cats
  • Electric Stimulation
  • Electroencephalography (drug effects)
  • Epilepsies, Partial (prevention & control)
  • Epilepsy, Generalized (prevention & control)
  • Hippocampus (physiology)
  • Kindling, Neurologic (physiology)
  • Microinjections
  • Receptors, Serotonin (drug effects, physiology)
  • Seizures (prevention & control)

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