Abstract |
This study assessed the effects of microinjections of a serotonin (5-HT) 1A agonist, 8-OH-DPAT, into the feline hippocampus (HIP) on seizure response induced by electrical stimulation of this region. Intra-HIP injection of 8-OH-DPAT (10 nmol) produced a significant elevation in the afterdischarge threshold of partial HIP seizures, with a significant reduction in the duration of focal afterdischarge. Similarly, microinjection of 8-OH-DPAT at the same dose significantly raised the seizure threshold for eliciting generalized seizures in HIP-kindled cats. The present results demonstrate that focally applied 8-OH-DPAT possesses a potent anticonvulsant action, and provide further evidence for the inhibitory role of 5-HT1A receptors in the generation of HIP seizures.
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Authors | Y Wada, M Nakamura, H Hasegawa, N Yamaguchi |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 159
Issue 1-2
Pg. 179-82
(Sep 03 1993)
ISSN: 0304-3940 [Print] Ireland |
PMID | 8264964
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticonvulsants
- Receptors, Serotonin
- 8-Hydroxy-2-(di-n-propylamino)tetralin
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Topics |
- 8-Hydroxy-2-(di-n-propylamino)tetralin
(administration & dosage, pharmacology)
- Animals
- Anticonvulsants
(administration & dosage, pharmacology)
- Cats
- Electric Stimulation
- Electroencephalography
(drug effects)
- Epilepsies, Partial
(prevention & control)
- Epilepsy, Generalized
(prevention & control)
- Hippocampus
(physiology)
- Kindling, Neurologic
(physiology)
- Microinjections
- Receptors, Serotonin
(drug effects, physiology)
- Seizures
(prevention & control)
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