[Sensitivity of bacteria causing urinary tract infections towards terizidon (author's transl)].

Abstract

In agar diffusion tests 2603 bacterial strains of species known to cause urinary tract infections were tested routinely in regard to their sensitivity towards Terizidon, a derivative of cycloserine. In order to relate the results which were obtained in terms of the diameter of the inhibiton zone, to the minimal inhibitory concentrations (MIC), 304 of these strains were tested additionally in agar dilution tests. The MICs of the other strains were estimated from the results of these tests. Since it is known that after the oral administration of 500 mg Terizidon the urine contains, on average, more than 128 mug/ml Terizidon for 12 hours and longer, it may be concluded from the results of this investigation that 75% of the strains of E. coli and Citrobacter, 45% of enterobacter, 40% of Proteus mirabilis and enterococci, 35% of the indole-positive Proteus strains and 30% of Pseudomonas aeruginosa would have been successfully attacked by Terizidon in the case or urinary tract infections. By contrast, Klebsiella must be reagarded as being completely resistant to this antibiotic. It follows that the administration of Terizidon is mainly indicated in the treatment of acute urinary tract infections with E. coli as the predominant causative agent.

• Authors: G Wewalka, M Rotter, A Fischer
• Journal: Wiener klinische Wochenschrift (Wien Klin Wochenschr) Vol. 88 Issue 11 Pg. 355-60 (May 28 1976) ISSN: 0043-5325 [Print] Austria
• Vernacular Title: Empfindlichkeit von Harnwegsinfekterregern gegen Terizidon
• PMID: 826024 (Publication Type: Journal Article)

Chemical References

• Oxazoles

Topics

• Citrobacter (drug effects)
• Enterobacteriaceae (drug effects)
• Escherichia coli (drug effects)
• Klebsiella (drug effects)
• Microbial Sensitivity Tests
• Oxazoles (pharmacology, therapeutic use, urine)
• Proteus mirabilis (drug effects)
• Pseudomonas aeruginosa (drug effects)
• Urinary Tract Infections (drug therapy)