[Antiemetic efficacy of granisetron in pediatric cancer treatment--(2). Comparison of granisetron and granisetron plus methylprednisolone as antiemetic prophylaxis].

Abstract

A crossover clinical trial was carried out to compare the effectiveness and safety of granisetron alone (40 micrograms/kg) with that from a combination of granisetron plus methylprednisolone (MPL, 10 mg/kg) for control of emesis and vomiting induced by anticancer drugs in children with cancer. Complete control of emesis and vomiting were achieved in 95% (19/20 cases) of patients receiving the combination compared to 85% (17/20 cases) of patients receiving granisetron alone. There were no clinical toxicities or side effects in either treatment group. These data indicated that the combination of granisetron plus MPL was superior for control of emesis and vomiting in children receiving cytostatic anticancer drugs.

• Authors: T Hirota, T Honjo, R Kuroda, K Saeki, N Katano, Y Sakakibara, H Shimizu, T Fujimoto
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 20 Issue 15 Pg. 2369-73 (Dec 1993) ISSN: 0385-0684 [Print] Japan
• PMID: 8259853 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Granisetron
• Methylprednisolone

Topics

• Adolescent
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Child
• Child, Preschool
• Drug Therapy, Combination
• Female
• Granisetron (administration & dosage)
• Humans
• Male
• Methylprednisolone (administration & dosage)
• Nausea (chemically induced, drug therapy, prevention & control)
• Neoplasms (drug therapy)
• Vomiting (chemically induced, drug therapy, prevention & control)