[Efficacy of 48-hour infusion of 5-fluorouracil for gall bladder cancer].

Abstract

Usefulness of an adjuvant chemotherapy for 23 patients who had undergone "non-curative" resection for adenocarcinomas of the gallbladder was investigated. Patients were divided into two groups: Group A (16 patients) was given MF (mitomycin C 6 mg/m2, 5-fluorouracil 250 mg/body) by injection on the 2nd and 9th postoperative day and received orally Tegafur 600 mg/day and PSK 3 g/day. Group B(7 patients) was treated weekly with a 48-hour infusion of 5-FU (1,000 mg/m2/24 hours), for 6 weeks and leucovorin (30 mg/body) was given for 2 hours prior to 5-FU infusion. The results were evaluated by the Kaplan-Meier method. Response rate of anti-tumor was 0% in Group A and 14.3% in Group B, including: PR, 1 and NC, 6 cases. The 50% survival time was 230 days in group A and 471 days in group B (p = 0.0008). The results suggest that treatment with 5-FU and LV is effective for gallbladder cancer.

• Authors: K Kato, A Koike, T Koide, T Kojima, Y Kawai, H Kuroda, K Tanaka, K Takeshige
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 20 Issue 15 Pg. 2341-4 (Dec 1993) ISSN: 0385-0684 [Print] Japan
• PMID: 8259848 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• Proteoglycans
• Tegafur
• polysaccharide-K
• Mitomycin
• Leucovorin
• Fluorouracil

Topics

• Adenocarcinoma (drug therapy, mortality, surgery)
• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemotherapy, Adjuvant
• Drug Administration Schedule
• Drug Evaluation
• Female
• Fluorouracil (administration & dosage, therapeutic use)
• Gallbladder Neoplasms (drug therapy, mortality, surgery)
• Humans
• Infusions, Intravenous (methods)
• Leucovorin (therapeutic use)
• Male
• Middle Aged
• Mitomycin (administration & dosage)
• Proteoglycans (administration & dosage)
• Remission Induction
• Survival Rate
• Tegafur (administration & dosage)