[Effect of ciprofloxacin therapy in duration of bacterial excretion in acute salmonella gastroenteritis].

Abstract

In view of the increasing incidence of non-typhoid salmonellosis, the effect of early treatment with ciprofloxacin on the permanent elimination of salmonella was evaluated. In a prospective study, 14 patients with non-typhoid salmonellosis were treated with 2 x 500 mg/d ciprofloxacin for 10 days within 5 days of onset of symptoms. Relapse occurred in 4/14 (29%) patients 2-3 weeks after termination of therapy. Using sero- and ribotyping, relapse was confirmed and reinfection ruled out in 4/4 patients. Furthermore, ribotyping suggested double infection in one patient. Development of resistance to ciprofloxacin was not observed. We conclude that the use of antimicrobial chemotherapy to treat non-institutional salmonellosis in immunocompetent patients cannot generally be recommended but must be considered carefully in each case. Indications for ciprofloxacin therapy in the treatment of non-typhoid salmonellosis are discussed.

• Authors: G Funke, P Nemes, J Lüthy-Hottenstein, M Altwegg
• Journal: Schweizerische medizinische Wochenschrift (Schweiz Med Wochenschr) Vol. 123 Issue 41 Pg. 1935-40 (Oct 16 1993) ISSN: 0036-7672 [Print] Switzerland
• Vernacular Title: Einfluss einer Ciprofloxacin-Therapie auf die Ausscheidedauer bei akuter Salmonellen-Gastroenteritis.
• PMID: 8259475 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ciprofloxacin

Topics

• Adult
• Ciprofloxacin (adverse effects, therapeutic use)
• Colony Count, Microbial
• Feces (microbiology)
• Female
• Gastroenteritis (drug therapy, microbiology)
• Humans
• Male
• Middle Aged
• Recurrence
• Salmonella (drug effects)
• Salmonella Infections (drug therapy, microbiology)