Porphyric neuropathy: prevention of progression using haeme-arginate.

Abstract

We report on a patient with acute intermittent porphyria (AIP) who, during treatment with hypertonic glucose, developed peripheral neuropathy. Once haeme-arginate was started, the progression of the neuropathy was attenuated. This suggests that hypertonic glucose may be inadequate in preventing the development of neuropathy in a patient with porphyria. However, haeme-arginate, if started early, can attenuate the progression of porphyric neuropathy.

• Authors: U B Muthane, B Vengamma, K C Bharathi, P Mamatha
• Journal: Journal of internal medicine (J Intern Med) Vol. 234 Issue 6 Pg. 611-3 (Dec 1993) ISSN: 0954-6820 [Print] England
• PMID: 8258754 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glucose Solution, Hypertonic
• Heme
• Arginine
• heme arginate

Topics

• Adult
• Arginine (therapeutic use)
• Glucose Solution, Hypertonic (therapeutic use)
• Heme (therapeutic use)
• Humans
• Male
• Peripheral Nervous System Diseases (drug therapy, etiology, prevention & control)
• Porphyria, Acute Intermittent (complications, drug therapy)