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Antitumoral effects of liarozole in androgen-dependent and independent R3327-Dunning prostate adenocarcinomas.

Abstract
We examined the in vivo antitumoral effects of liarozole against androgen-dependent and independent Dunning rat prostatic tumors. Liarozole, applied as a dietary admixture, at a dose of 120 mg./100 gm. food, equivalent to 100 mg./kg. per day, inhibited the growth of the slow growing, well-differentiated, androgen-dependent Dunning-H tumor (median tumor volume decrease of 60%). At the same dose it also significantly reduced the growth of the androgen-independent, moderately differentiated PIF-1 (-60%) and androgen-independent, anaplastic AT-6 tumors (-73%). The growth of AT-6 sq tumor showing squamous metaplasia was unaffected by liarozole. When administered by oral gavage, liarozole at 40 (-82%) mg./kg. twice a day was as effective as castration (-92%) in reducing the androgen-dependent, poorly differentiated Dunning R3327-G tumor. Liarozole, administered by gavage, twice a day, also significantly reduced median tumor volume in the androgen-independent, AT-6 sq (-90% at 60 mg./kg., twice a day). This difference between liarozole administration by gavage and food admixture will have to be taken into account in further experimental studies. Inhibition of the growth of several androgen-dependent and, chiefly, androgen-independent Dunning prostate carcinoma sublines that differ widely in their histological degree of differentiation and growth rate suggests that liarozole may be a suitable agent for evaluation in second line treatment of hormone refractory prostate carcinoma in patients who relapse after androgen ablation.
AuthorsG A Dijkman, R J Van Moorselaar, R Van Ginckel, P Van Stratum, L Wouters, F M Debruyne, J A Schalken, R de Coster
JournalThe Journal of urology (J Urol) Vol. 151 Issue 1 Pg. 217-22 (Jan 1994) ISSN: 0022-5347 [Print] United States
PMID8254818 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Androgens
  • Antineoplastic Agents
  • Imidazoles
  • liarozole
Topics
  • Adenocarcinoma (drug therapy)
  • Androgens
  • Animals
  • Antineoplastic Agents (therapeutic use)
  • Imidazoles (therapeutic use)
  • Male
  • Neoplasm Transplantation
  • Neoplasms, Hormone-Dependent (drug therapy)
  • Prostatic Neoplasms (drug therapy)
  • Rats
  • Tumor Cells, Cultured

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