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Activity of newer aminoglycosides and carbenicillin, alone and in combination, against gentamicin-resistant Pseudomonas aeruginosa.

Abstract
The in vitro activity of the aminoglycoside antibiotics tobramycin, sisomicin, amikacin, gentamicin, and netilmicin (SCH 20569) were compared against 26 gentamicin-resistant isolates of Pseudomonas aeruginosa cultured from hospitalized children. Tobramycin had the greatest activity on a weight basis, followed by sisomicin, gentamicin, amikacin, and netilmicin. All isolates were resistant to achievable concentrations of netilmicin and gentamicin, but 23% were inhibited by achievable concentrations of tobramycin, 8% by amikacin, and 4% by sisomicin. The combinations carbenicillin/tobramycin, carbenicillin/sisomicin, and carbenicillin/amikacin were synergistic for 92% of strains; antagonism was not encountered. These in vitro results suggest that tobramycin, sisomicin, or amikacin in combination with carbenicillin would be the safest initial regimen in the therapy of gentamicin-resistant Pseudomonas infections pending susceptibility studies.
AuthorsM I Marks, S Hammerberg, G Greenstone, B Silver
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 10 Issue 3 Pg. 399-401 (Sep 1976) ISSN: 0066-4804 [Print] United States
PMID825026 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Aminoglycosides
  • Anti-Bacterial Agents
  • Gentamicins
  • Amikacin
  • Carbenicillin
  • Tobramycin
  • Sisomicin
Topics
  • Amikacin (pharmacology)
  • Aminoglycosides (pharmacology)
  • Anti-Bacterial Agents (pharmacology)
  • Carbenicillin (pharmacology)
  • Gentamicins (pharmacology)
  • Penicillin Resistance
  • Pseudomonas aeruginosa (drug effects)
  • Sisomicin (analogs & derivatives, pharmacology)
  • Tobramycin (pharmacology)

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