Abstract |
The in vitro activity of the aminoglycoside antibiotics tobramycin, sisomicin, amikacin, gentamicin, and netilmicin ( SCH 20569) were compared against 26 gentamicin-resistant isolates of Pseudomonas aeruginosa cultured from hospitalized children. Tobramycin had the greatest activity on a weight basis, followed by sisomicin, gentamicin, amikacin, and netilmicin. All isolates were resistant to achievable concentrations of netilmicin and gentamicin, but 23% were inhibited by achievable concentrations of tobramycin, 8% by amikacin, and 4% by sisomicin. The combinations carbenicillin/ tobramycin, carbenicillin/ sisomicin, and carbenicillin/ amikacin were synergistic for 92% of strains; antagonism was not encountered. These in vitro results suggest that tobramycin, sisomicin, or amikacin in combination with carbenicillin would be the safest initial regimen in the therapy of gentamicin-resistant Pseudomonas infections pending susceptibility studies.
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Authors | M I Marks, S Hammerberg, G Greenstone, B Silver |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 10
Issue 3
Pg. 399-401
(Sep 1976)
ISSN: 0066-4804 [Print] United States |
PMID | 825026
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Aminoglycosides
- Anti-Bacterial Agents
- Gentamicins
- Amikacin
- Carbenicillin
- Tobramycin
- Sisomicin
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Topics |
- Amikacin
(pharmacology)
- Aminoglycosides
(pharmacology)
- Anti-Bacterial Agents
(pharmacology)
- Carbenicillin
(pharmacology)
- Gentamicins
(pharmacology)
- Penicillin Resistance
- Pseudomonas aeruginosa
(drug effects)
- Sisomicin
(analogs & derivatives, pharmacology)
- Tobramycin
(pharmacology)
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