Rearrangement by chromosomal inversion in the T cell receptor gamma locus in a murine alpha beta T cell clone.

Abstract

Analyzing the T-cell receptor (TCR) repertoire of T lymphocytes specific for minor histocompatibility antigens, we isolated a TCR-alpha beta bearing T cell clone, TGVH9, which also expresses three different TCR-gamma mRNA. The sequences of these messengers indicate that one of them results from the rearrangement of V gamma 1 and J gamma 2 genes. Since these two segments are in inverted genomic transcriptional orientation, the joining of V gamma 1 to J gamma 2 occurred by chromosomal inversion. This mechanism, which was previously reported in TCR-beta and TCR-delta loci, can thus also occur to enlarge the diversity of the TCR-gamma repertoire.

• Authors: T Roger, I Miconnet, M Bruley-Rosset, M Seman
• Journal: Molecular immunology (Mol Immunol) Vol. 30 Issue 17 Pg. 1617-20 (Dec 1993) ISSN: 0161-5890 [Print] England
• PMID: 8247032 (Publication Type: Journal Article)

Chemical References

• Receptors, Antigen, T-Cell, alpha-beta
• Receptors, Antigen, T-Cell, gamma-delta

Topics

• Amino Acid Sequence
• Animals
• Base Sequence
• Chromosome Inversion
• Clone Cells
• Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor (genetics)
• Gene Rearrangement, beta-Chain T-Cell Antigen Receptor (genetics)
• Mice
• Mice, Inbred DBA
• Molecular Sequence Data
• Receptors, Antigen, T-Cell, alpha-beta (genetics)
• Receptors, Antigen, T-Cell, gamma-delta (genetics)