Glioblastoma multiforme of donor origin after renal transplantation: report of a case.

Abstract

A case of transmission of a glioblastoma multiforme from the donor to a kidney transplant recipient in the absence of previous ventriculosystemic shunt is described. The recipient was a 48-year-old woman who developed a fever with no other associated symptoms 17 months posttransplant. Physical examination revealed a large nonpulsatile mass on the upper graft pole. Histopathologic examination showed a highly cellular neoplasm with fusiform and globoid cells, a high grade of nuclear pleomorphism and mitosis, necrosis with pseudopalisading, and vascular proliferation. Immunohistochemistry of the cells showed them to contain glial fibrillary acidic and S-100 proteins, consistent with a glioblastoma multiforme. We conclude that the risk of tumor transmission from donors with primary central nervous system tumors to kidney transplant recipients, is real and should be considered when evaluating a graft mass in such patients.

• Authors: F Val-Bernal, J C Ruiz, J G Cotorruelo, M Arias
• Journal: Human pathology (Hum Pathol) Vol. 24 Issue 11 Pg. 1256-9 (Nov 1993) ISSN: 0046-8177 [Print] United States
• PMID: 8244327 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glial Fibrillary Acidic Protein
• S100 Proteins

Topics

• Adult
• Female
• Glial Fibrillary Acidic Protein (analysis)
• Glioblastoma (chemistry, etiology, pathology)
• Humans
• Immunohistochemistry
• Kidney Neoplasms (chemistry, etiology, pathology)
• Kidney Transplantation (adverse effects, pathology)
• Male
• Middle Aged
• S100 Proteins (analysis)
• Tissue Donors