Low-dose aspirin fails to inhibit increased platelet reactivity in patients with peripheral vascular disease.

Abstract

A study was performed to evaluate the effect of low-dose aspirin (75 mg/day) on platelet reactivity in patients with peripheral vascular disease. Platelet function was measured in 31 patients with advanced peripheral vascular disease requiring surgery. Shear-induced haemostasis and collagen-induced thrombus formation were used as indicators of platelet reactivity. They were measured in non-anticoagulated fresh whole blood samples ex vivo using a haemostatometer. Results were compared with those from 30 age- and sex-matched controls. Shear-induced haemostasis and collagen-induced thrombus formation were also measured in 18 of the 31 patients before the start of aspirin administration (before operation) and 1 week after surgery. Patients with advanced peripheral vascular disease were found to have increased platelet reactivity with a mean(s.e.m.) shear-induced haemostasis index of 1977(180) mmHg s compared with a control value of 3161(234) mmHg s (P < 0.001) and a mean(s.e.m.) collagen-induced thrombus formation index of 3980(460) mmHg s compared with a control value of 5350(420) mmHg s (P = 0.02). Perioperative low-dose aspirin failed to inhibit platelet function in patients with peripheral vascular disease.

• Authors: T K Walters, D C Mitchell, R F Wood
• Journal: The British journal of surgery (Br J Surg) Vol. 80 Issue 10 Pg. 1266-8 (Oct 1993) ISSN: 0007-1323 [Print] England
• PMID: 8242294 (Publication Type: Journal Article)

Chemical References

• Collagen
• Aspirin

Topics

• Aged
• Aspirin (administration & dosage, pharmacology)
• Blood Coagulation (drug effects)
• Blood Platelets (drug effects)
• Collagen (pharmacology)
• Drug Administration Schedule
• Female
• Hemostasis (drug effects)
• Humans
• Male
• Middle Aged
• Peripheral Vascular Diseases (blood, surgery)
• Platelet Activation (drug effects)